Several BET inhibitors, such as CPI-0610 (Constellation Pharmaceuticals, Cambridge, MA, USA) (NCT02158858; AML and MDS), MK-8628 (Merck and Co., Inc., Whitehouse Station, NJ, USA) (NCT02698189; AML, MDS, and diffuse large B-cell lymphoma), and R06870810 (Roche, Basel, Switzerland) (NCT02308761; AML and MDS) are being tested in early clinical trials in AML and other hematologic malignancies, including myelodysplastic syndromes. This evidence concerns the gene DNER and acute myeloid leukemia.