PIK3C2A and cardiac hypertrophy: On the other hand, protective action of GA on diabetes- induced myocardial dysfunction attributed to attenuating of serum levels of CPK, CK-MB, and LDH, cTnT, BS, and decreasing MDA levels, myocardial hypertrophy, infarct size and increasing antioxidant activity of SOD, CAT, GPx, and hemodynamic parameters such as LVP, LVEDP, LVSP, LVDP, RPP and vasodilatory response.