In addition, GA has regulatory action on cardiac hypertrophy and hypertension through reducing serum levels of CPK, CK-MB, LDH, cTnT, cardiac hypertrophy, infarct size, and down-regulating of p-JNKs, p- ERK, GATA6 and modulating of hemodynamic parameters including LVP, LVEDP, LVSP, LVDP, RPP. This evidence concerns the gene PIK3C2A and hypertensive disorder.