Recently upregulation of IL1R2 has been observed in different cancers, such as pancreatic ductal adenocarcinoma, prostate cancer, ovarian cancer and BC,10, 27 and regulates tumor angiogenesis and proliferation.12, 28 However, the functional consequences of IL1R2 in BC have not yet been addressed. Here, IL1R2 is linked to pancreatic ductal adenocarcinoma.