Although previous report showed that IL1R2 inhibits IL1‐mediated NFκB signaling and interacts with c‐Fos via its intracellular domain,12 our gene set enrichment analysis (GSEA) has not showed significant change of c‐Fos‐related signaling in these BC cells (data not shown) and we did find that target genes enriched for NFκB signaling and inflammatory response were downregulated in IL1R2‐overexpressing cells (Figure3A). The gene discussed is IL1A; the disease is breast cancer.