Vesicle shells were modified with an antibody against CD80 (CD80 Ab) (Figure1), which is expressed on APCs, including DCs28 and monocytes.29 The therapeutic efficacy of endogenous antigen‐carrying nanoparticles (EAC‐NPs) was evaluated in subcutaneous mastadenoma model and pulmonary metastatic melanoma model. The gene discussed is CD80; the disease is metastatic melanoma.