In the SCI_P group vs. SCI_C group, only the “ECM-receptor interaction” was enriched in the upregulated DEGs (Fig. 7C; Table S5); the downregulated DEGs were enriched in CAMs, malaria, leukocyte transendothelial migration, ECM-receptor interaction, PI3K-Akt signaling pathway, hematopoietic cell lineage, focal adhesion, Rap1 signaling pathway and amebiasis (Fig. 7D; Table S5). Here, AKT1 is linked to amebiasis.