LCN2 encodes neutrophil gelatinase‐associated lipocalin (NGAL), which suggests increased neutrophil‐mediated antibacterial activity; NGAL is also a biomarker of kidney injury.30 Gene set enrichment analysis of patients with flares suggested increased inflammatory signalling (e.g. IL‐6 and TNF‐α), increased proliferation signalling (KRAS) and haematological disturbances (haem metabolism, coagulation, complement and platelet‐related gene sets) (Supplementary figure 11). This evidence concerns the gene KRAS and kidney injury.