In addition, we also overexpressed SNHG6 in ox-LDL-induced HUVECs, and the results revealed that SNHG6 overexpression aggravated ox-LDL induced injury of HUVECs, which was contrary to SNHG6 knockdown (Additional file 1: Figure S1). These findings suggested that knockdown of SNHG6 greatly alleviated ox-LDL-induced atherosclerosis events through inhibiting inflammatory and oxidative stress. Here, SNHG6 is linked to atherosclerosis.