Genes implicated in ASD such as Annexin 1 (ANXA1) (50), HLA-B [55, 70] and CNTN6 with deletion or duplication in a spectrum of neurodevelopmental disorders and ID [71, 72] were upregulated in TSC1-Het and Null NPCS when compared with the WT. The gene discussed is CNTN6; the disease is neurodevelopmental disorder.