Moreover, treatment with rapalogs, the current standard of care for TSC patients, may lead to adaptive changes in neuronal cells via signaling feedback mechanisms, and future translatome (referring to mRNAs being actively translated) studies performed before and after mTOR and MNK inhibitor treatment in TSC patient-derived NPCs could be valuable in providing in-depth information regarding distinct translational changes. This evidence concerns the gene ATP7A and tuberous sclerosis.