Recent studies demonstrated that a single, conserved Ser residue (S209) in the Eukaryotic Translation Initiation Factor 4E (eIF4E), phosphorylated by MAP kinase-interacting kinase (MNK) [50] not only plays a role in cancer biology, but also in neurobiology by regulating 5’ cap-dependent translation of specific mRNAs in neuronal cells [51]. This evidence concerns the gene ATP7A and cancer.