NAMPT and acute myeloid leukemia: In November 2013, Matheny et al reported that nicotinamide phosphoribosyl transferase (NAMPT), a key enzyme in NAD biosynthesis, had been identified as the primary target of compound STF-118804 by screening MV411 acute monocytic leukemia (AML) cells with high doses of the compound and looking for synthetic lethal drug-gene interactions [33].