While exosomes have been documented to have different tropisms for localization and uptake based on patterns of integrin expression [110], we have yet to determine if miR-142-3p is indeed released from immune cell exosomes into tumor or stromal fibroblasts in this context, or if the quantity would be sufficient to downregulate CLIC4 to the extent observed within tumors. The gene discussed is CLIC4; the disease is neoplasm.