CLIC4 has been implicated in angiogenesis [3–5], pulmonary arterial hypertension [6, 7], epithelial differentiation [8], myofibroblast differentiation [9–11], response to oxidative stress [12–15], cellular adhesion and integrin trafficking [16–18], immunity [19–22], and cancer [23–31]. Here, CLIC4 is linked to cancer.