We used ENCODE data to analyze protein binding near the CLIC4 promoter and identified binding by members of transcription factor families with known involvement in cancer such as MYC (MYC, MAX), p53 (TP53), AP-1 (FOS, JUN, JUNB, JUND, ATF2), NF-κB (RELA), CTCF, PAX5, and RUNX3 [60]. The gene discussed is FOS; the disease is cancer.