We surveyed several HNSCC cell lines (SCC4, 9, 15, and 25) and found that while CLIC4 is moderately abundant in vitro, its protein level can be downregulated by the addition of miR-142-3p mimic, to a level comparable or greater than that of a CLIC4 siRNA (Figure 5B). Here, CLIC4 is linked to head and neck squamous cell carcinoma.