After describing the altered cellular proliferation and migration behaviors of MDA-MB-231 cells with knockdown of ADK isoforms, we further demonstrated that ADK-L strongly affects multiple gene expressions - including CCND2, MMP9, ADAM23, THBS1, and CST6 - that are relevant to cancer cell proliferation and migration/invasion (Figure 5 and Table 1). The gene discussed is CST6; the disease is cancer.