In response to low-dose CY, we observed a reduction in the frequency of total NK cells in the tumor, relative to saline control treated tumor-burdened mice (Supplementary Figure 1); however, a higher proportion of these NK cells were activated in low-dose CY-treated tumor and blood, as indicated by their expression of TBET and CD107a, reaching a statistical significance at a dose of 40 mg/kg (Figure 1D). Here, LAMP1 is linked to neoplasm.