NOS2 and neoplasm: Similar correlations were observed between tumor volume and the expression of Th1 chemokines (Cxcl9, Cxcl10), adhesion molecules (Icam1) and the M1 macrophage marker Nos2. In contrast, increased tumor growth inhibition correlated with decreased expression of pro-tumorigenic molecules Cox2 and Il11. Overall, the global gene expression changes modulated by the combination treatment strongly favored systemic antitumor immunity, resulting in tumor growth inhibition at the non-injected site.