C3 and neoplasm: In the non-injected tumor, combination treatment resulted in up-regulation of 15 out of 18 genes in the complement pathway including anaphylatoxin receptors (C3ar1, C5ar1), complement regulators (Cfh, Cfp), and further up-regulation of C3, which is a central node in the complement cascade on which both classical and alternative pathways converge (Supplementary Figure 3D).