The activity of ATX-101 is not specific for the 67NR cells as ATX-101 also enhanced the effect of AEE788 in three other human cancer cell lines overexpressing EGFR; the human colon cancer cell line SW480, the human bladder cancer cell line 5637 and the human breast cancer cell line MDA-468 (Figure 1C). This evidence concerns the gene EGFR and malignant colon neoplasm.