After additional adjustment for biochemical indicators, subjects in the highest quartile of RBP4 had 3.72-fold (95% CI, 1.27~10.87; P-trend = 0.005) and 3.25-fold (95% CI, 1.02~10.34; P-trend = 0.026) higher risk of developing GDM, respectively. Here, RBP4 is linked to gestational diabetes.