AKT1 and carcinoma: To determine whether miR-30b-3p could affect PI3K/Akt signalling, we first observed that the protein levels of TRIM27 and p-Akt were both highly expressed in HCC tissues compared with non-carcinoma tissues (Figure 6A), indicating that PI3K/Akt signalling might be activated when TRIM27 is overexpressed HCC tissues.