TRIM27 and hepatocellular carcinoma: Further, to investigate the role of TRIM27 in HCC cell migration and invasion, the Transwell migration and invasion assay revealed that, compared with the empty vector group, TRIM27 overexpression promoted the malignant phenotypes of HCC cells remarkably, whereas TRIM27 knockdown decreased the migratory and invasive activities of HCC cells (Figures 5D, E).