TBC1D16 and obesity due to melanocortin 4 receptor deficiency: Among the 13 genes showing association between DNA methylation and gene expression, the TBC1D16 gene was described to be dysregulated in obesity (Pietiläinen et al., 2016; Crujeiras et al., 2017) and contains the highest number of DMRs (5 in total) [Figures 4 and 7A and Supplementary Table S3(4-5)].