However, these effects of IL8 must be achieved by binding to the corresponding receptors; during this process, IL8RB is the receptor gene of IL8. Moreover, IL8RB has exhibited an important role in immune function during mastitis infection, and it belongs to the promising candidate genes contributing in bovine mastitis (El Nahas et al., 2017). This evidence concerns the gene CXCR2 and Bovine mastitis.