IL4 and neoplasm: This fact prompted several investigations aimed at assembling T cells with cytokine receptors such as CSF-1 (3) or inverted cytokine receptors IL-4Ralpha ectodomain/IL-2 beta(c) endodomain (4), IL4/IL7 (5), or IL4/IL21 (6) among others, to respond positively to ligands expressed into the tumor.