In agreement with previous reports, we found that CD4+ T cells accumulate in colorectal tumors, compared with normal tissues but were lower compared to their levels in circulation (PBMC; 31.4 ± 2.0 vs. NILs; 11.5 ± 1.0 vs. TILs; 22.0 ± 2.1, Figure 1A). This evidence concerns the gene CD4 and colorectal neoplasm.