Nonetheless, pembrolizumab, an immune checkpoint (IC) inhibitor [anti-programmed cell death protein 1 (PD-1)], was recently granted Food and Drug Authority (FDA) approval for treating unresectable or metastatic solid tumors, including CRC, with microsatellite instability high (MSI-H) or DNA mismatch repair deficiency (dMMR) (8, 9). The gene discussed is PDCD1; the disease is hyperinsulinemic hypoglycemia, familial, 4.