Saito et al. proposed that these results could be attributed to different subsets of tumor-infiltrating FoxP3+ Tregs, which include FoxP3high and FoxP3low Tregs; the former representing stable FoxP3 expression, while FoxP3low non-suppressive Tregs secrete inflammatory cytokines and henceforth may be associated with improved clinical outcomes in CRC (14). Here, FOXP3 is linked to neoplasm.