Nine hallmarks could be related to tumor immunology and collectively showed a decreased expression over time (allograft rejection, complement, IL2-STAT5 signaling, IL-6-JAK-STAT3 signaling, inflammatory response, IFN-α response, IFN-γ response, KRAS signaling up, and TNF-α signaling via NF-κB) (Figure 9). The gene discussed is STAT3; the disease is neoplasm.