CHI3L1 and neoplasm: CHI3L1 and LCN2 levels in spleens corroborated the increased splenomegaly at 3 and 6 w p.i. in the 4T1- compared to the Py230-based intraductal model (Figure 4E) and further indicated the presence of enhanced leukocyte reactions in the 4T1 tumor-bearing mice.