Similarly, CD163 stainings demonstrated a progressive increase of tumor-associated macrophages (TAMs) in the surrounding primary tumor stroma, with 4T1 primary tumors showing significantly higher CD163 positivity at 1 and 3 w p.i., but not at 6 w p.i. compared to Py230 primary tumors (Figure 6). The gene discussed is CD163; the disease is neoplasm.