More specifically, all 9 tumor immunology-related gene sets remained upregulated in 4T1 compared to Py230 primary tumors across the 3 time points, but only significantly at 1 and/or 3 w p.i. Other gene sets could be related to cellular mitosis and tumor progression, including DNA repair, E2F targets, G2M checkpoint, mitotic spindle, MTORC1 signaling, MYC targets V1 and spermatogenesis (Figure 9). This evidence concerns the gene MYC and neoplasm.