Viel et al. showed that while TGFβ had no effect on the development of murine NK cells, genetic deletion of the TGFβR2 (specifically in NK cells via Ncr1Cre mice crossed with TGFβR2fl/fl mice) reduced tumor metastasis in two tumor models and increased nutrient receptor expression and mTORC1 activity in IL15 stimulated NK cells (46). This evidence concerns the gene IL15 and neoplasm.