Notwithstanding its importance at barrier sites, TSLP is well-established as an inducer of Th2 cytokine driven allergic inflammation such as atopic dermatitis, eosinophilic esophagitis, asthma and allergic rhinitis, all mediated by a variety of cells including eosinophils, basophils, and ILC2s (16, 48, 100, 103, 104). Here, TSLP is linked to asthma.