KCs are a key source of IL-1β and caspase 1, a critical NLR3 component that regulates downstream proinflammatory signaling (e.g., pro-IL-1β, pro-IL-18, ASC), and are elevated in livers from NASH patients (105, 108, 109). The gene discussed is IL1B; the disease is metabolic dysfunction-associated steatohepatitis.