NOS2 and metabolic dysfunction-associated steatotic liver disease: Accounting for the considerable influx of inflammatory macrophages in NAFLD, future studies aimed at addressing macrophage-specific modulation of L-ARG metabolism with existing molecular tools (e.g., Arg1flox, Aslflox, Nos2-deficient) (148–150) will be necessary to dissect how various macrophage populations manipulate the liver microenvironment and NAFLD progression.