The autoantibodies included in the classification criteria for antiphospholipid syndrome (APS) are the presence of lupus anticoagulant, or the presence of IgG or IgM isotype antibodies directed against cardiolipin (aCL) or against B2-Glycoprotein I (aB2GP1) (5, 6). The gene discussed is CD40LG; the disease is autoimmune polyendocrinopathy.