Searching for new biomarkers that would allow a better identification of the population at risk, circulating immune complexes (CIC) of IgA bound to B2GP1 (B2A-CIC) were described in the blood of patients with APS symptomatology (22) and its presence was associated with the occurrence of acute thrombotic events (23). This evidence concerns the gene KRTAP1-1 and autoimmune polyendocrinopathy.