At least in preclinical animal research, targeting VWF via anti-VWF-GPIbα strategies or recombinant ADAMTS13 did not increase the risk of intracranial hemorrhaging in murine stroke models (42, 43, 49), even when combined with tissue-plasminogen activator (87, 88) or when treatment was delayed (56). Here, ADAMTS13 is linked to stroke disorder.