TNF and neoplasm: Silencing PlGF in mice reduces tumor associated macrophage (TAM)-related chemokines and receptors (CXCL10, ICAM-1, VCAM, and CCR2), pro-inflammatory molecules (TNF-α, IL-1β, CCL2), and even anti-microbial receptors (TLR4 and TLR9), emphasizing the crucial role of this molecule and thus its potential as a therapeutic target (40).