Likewise, as shown in Figure 1C, we observed significantly higher levels of caspase-3 activity (p < 0.0001) in all the considered CPC population in BS patients with respect to controls (CD34+/CD45−/dim: 8704 ± 3158 vs. 323 ± 66; CD34+/CD45−/dim/CD133–: 12,318 ± 5280 vs. 304 ± 73; CD34+/CD45−/dim/CD133+: 2197 ± 1002 vs. 3274 ± 67). Here, PROM1 is linked to Bloom syndrome.