For example, stimulation of hepatocyte growth factor (HGF) in colorectal cancer cells (CRCs) promotes phosphorylation of β-catenin in tyrosine residue and its dissociation from Met (HGFR is encoded by proto-oncogene MET) and thus upregulates β-catenin expression via the PI3-K pathway. The gene discussed is HGF; the disease is colorectal cancer.