Also, this drug downregulated survivin, an inhibitor-of-apoptosis protein, (IAP) in primary ALL and, in combination with conventional therapy and independently of the mutational status of CBP and chromosomal aberration, eradicates drug-resistant primary leukemia in vitro and prolongs the survival of NOD/SCID mice inoculated with primary ALL (183–185). This evidence concerns the gene BIRC5 and acute lymphoblastic leukemia.