ISG15 and systemic lupus erythematosus: The IFN-related genes most highly affected by DHA in this study have been associated with human SLE, including Irf7 (55, 56), Oas2 (57–60), Ifi44 (60–63), Ifit1 (64), Ifit3 (64), Isg15 (65), Nrlc5 (66), and Mx2 (67).