Network analysis revealed that DHA had robust effects on critical genes associated with glomerulonephritis including those related to IFN signaling (e.g., Irf7, Ifit1, Oas2, Isg15); cytokines and chemokines (e.g., Ccl8, Ccl2, Ccr2, Cx3cr1); and antigen processing and MHC (e.g., H2-Dmb2, Fcgr1, Fcer1g, H2-Eb1) (Figure 13A). This evidence concerns the gene ISG15 and glomerulonephritis.