In a recent study, aiming to elucidate the role of the T-cell inhibitory receptor CTLA-4 in pathogenesis of glomerulonephritis, a major cause of CKD, levels of IgM inversely correlated with lower CTLA-4, as did IgG and IgA to a lesser extent, with the proposition that this may reflect inappropriate IgM function in ESRD (267). The gene discussed is CD40LG; the disease is chronic kidney disease.