This continuum can be loosely grouped into active TB, subclinical TB, incipient TB, latent TB, and “Resisters.” Individuals with active TB have detectable bacillary burden by culture or PCR and commonly have a positive interferon-γ (IFN-γ) releasing assay (IGRA) or tuberculin skin test (TST) with cough, weight loss, and fever. This evidence concerns the gene IFNG and tuberculosis.