Since NSCLC cells facilitate the production of IL-10 and IL-27 in CD1c+ DCs (Figures 6B,E), NSCLC cells may block the activity of CD8+ T cells and elicit the development of CD4+ Tregs through IL-10 and IL-27 produced by CD1c+ DCs in vivo. The gene discussed is IL27; the disease is non-small cell lung carcinoma.