CD40 and non-small cell lung carcinoma: Since our results indicate that H-1299 tumor cells downregulate the expression of CD40, CD80, CD86, and HLA-DR on CD1c+ DCs isolated from healthy donors (Supplementary Figure 4), we proposed that H-1299 cells may also block the expression of costimulatory molecules on CD1c+ DCs derived from NSCLC patients.