The first EWAS in BD showed that CD4+ T cells and monocytes extracted from the peripheral blood of BD patients were hypomethylated in genes associated with cytoskeletal remodeling, cell migration, and tissue invasion, such as RAC1, RGS14, and FSCN2. Some methylation deficiencies return to normal level during disease remission. This evidence concerns the gene RGS14 and Behcet disease.