Viperin is an evolutionarily conserved iron-sulfur (Fe-S) cluster-binding protein (13–15), which can be induced in various cell types by distinct stimuli of IFN-I and IFN-II, viral DNA, dsRNA, polyI:C, LPS, and by infection with diverse viruses, such as human cytomegalovirus (HCMV) (16), pseudorabies virus (17), Japanese encephalitis virus (18), West Nile virus (19), hepatitis C virus (HCV) (15), Chikungunya virus (20), rhinovirus (21), yellow fever virus (22), lymphocytic choriomeningitis virus (23), and dengue virus (DENV) (24). Here, RSAD2 is linked to infection.