RSAD2 and infection: Thus, we can not study the interaction mechanism between gD and viperin during HSV-1 mutant (gD deletion or knockdown) infection (3, 8, 9), since it is difficult for us to determine whether the effect of gD-viperin interaction on the proliferation of HSV-1 (after gD knockdown or deletion) is caused by the decrease of gD and viperin interaction or the reduce of gD directly affects the propagation of HSV-1.