A change occurred in the polarization of TAMs to a more antitumoral phenotype as defined by a reduced percentage of tumor-associated M2 macrophages (CD11b+, Ly6G–, F4/80+, CD206+) after CCL2/CCL12 blockade in an animal flank tumor model in which mice were injected in the right flank with tumor cells and tumors were treated with anti-CCL2/anti-CCL12 antibodies or saline as control. Here, ITGAM is linked to neoplasm.