CD4 and HIV infectious disease: However, eliminating HIV infection remains an elusive goal due to the viral reservoir—HIV proviral DNA in the host genome of resting CD4+ T lymphocytes and possibly other cells (Bukrinsky et al., 1991; Chun et al., 1997, 1998; Finzi et al., 1997; Wong et al., 1997b; Finzi et al., 1999; Ganor et al., 2019).