More detail studies found that the non-active form of TB response including LTBI or BCG vaccination and treated TB are associated with predominant CD4+IFN-γ+IL-2+ TEM and CD4+IL-2+ TCM; whilst active TB is associated with predominantly CD4+IFN-γ+ TEMRA cells (Sutherland et al., 2009; Caccamo et al., 2010; Casey et al., 2010; Sester et al., 2011). This evidence concerns the gene CD4 and tuberculosis.