Besides, other studies have shown that the ratio of IFN-γ and IL-10 (Sai Priya et al., 2010), ratio of IL-2 and IFN-γ (Wu et al., 2017), IL-8, IP-10, MIP-1α, sIL-2Rα, vascular endothelial growth factor (VEGF), MCP-3 (Yao et al., 2017; Hoel et al., 2019) as well as soluble markers to TLR-4 pathway such i.e., sCD14, MD-2, and LPS (Feruglio et al., 2013) can distinguish between active TB and LTBI and can also correlate with treatment success. This evidence concerns the gene IL2 and tuberculosis.