Similarly, short-term treatment of curcumin significantly attenuates diabetes-induced levels of vasoactive factors (endothelin-1 and eNOS), TGF-β1, ECM proteins (fibronectin), and oxidative stress markers (heme oxygenase-1, nitrotyrosine, and 8-OHdG) in kidneys (19). The gene discussed is FN1; the disease is diabetes mellitus.