EDN1 and diabetes mellitus: We found that when compared to untreated diabetic controls, IL-6 (Figure 6A), TNF-α (Figure 6B), FN (Figure 6C), VEGF-A (Figure 6E), ET-1 (Figure 6F), and p300 (Figure 6G) transcripts were significantly dampened in renal cortical tissues after L2H21 or L50H46 treatment at 2 months of diabetes; while, curcumin treatment only demonstrated significant downregulations in IL-6, FN, VEGF-A, and p300 transcripts.