SNORD116 and Prader-Willi syndrome: Also, a recent study reported Snord116-deficient mice with decreased activity of the hypothalamic prohormone convertase PC1 impairing the prohormone processing of proinsulin, pro-GH-releasing hormone, and proghrelin, pointing to an important part of SNORD116 and PC1 deficiency in the main neuroendocrine features of PWS (133).