Overall, the hormonal conditioning process that was found to occur in athletes, and identified by enhanced GH, prolactin and cortisol responses to exercise-independent stimulation tests, when compared to sex-, age-, and BMI-matched healthy sedentary controls, and adjusted for body composition, may be one of the underlying reasons for decreased extracellular water, decreased anger, fatigue, depression, confusion mood states, and indirect account for reduced fat, increased muscle, and better hydration (38). This evidence concerns the gene GH1 and major depressive disorder.