The PI3K-AKT pathway has been proposed to play an important role in the metabolic pathway of pituitary tumors, and future clinical studies should focus on the PI3K-AKT pathway for drug research and individualized treatment (61), which was consistent with our results regarding the overlapped molecule (DEG; protein)—AKT gene was upregulated in NFPAs compared to controls. The gene discussed is AKT1; the disease is pituitary tumor.