Used for elevation in intraocular pressure, vitreous hemorrhage, glaucoma, cataract surgery Used increasingly in the treatment of diabetic macular edema refractory to anti-VEGF therapy alone FDA approved indications in gastroenterology (Crohn's disease, ulcerative colitis) rheumatology (rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis), and dermatology (plaque psoriasis). This evidence concerns the gene VEGFA and glaucoma.