VEGFA and ankylosing spondylitis: Used for elevation in intraocular pressure, vitreous hemorrhage, glaucoma, cataract surgery Used increasingly in the treatment of diabetic macular edema refractory to anti-VEGF therapy alone FDA approved indications in gastroenterology (Crohn's disease, ulcerative colitis) rheumatology (rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis), and dermatology (plaque psoriasis)