ADIPOR1 and Cognitive impairment: Secondly, they identified AdipoR1/TLR4/NFκB, AdipoR1/AMPK/SIRT1/SREBP2 signaling, and AdipoR1 interfered Nogo-receptor 1 (Ng1) signaling are three key pathways that responsible for osmotin diminished neuroinflammation and Aβ accumulation while improved neurodegenerative disease related, synaptic deficits, cognitive impairment, memory loss and long-term potentiation (189–192).