Network 1 mainly functioned in cancer, organismal development, and vascular system development and function, which contained 35 nodes (genes; proteins), 23 nodes (66%) were identified in this network, and ERK1/2, STAT5a/b, GH1, PRL, PLC, growth hormone, LH, ADCY, proinsulin, FSH, Cg, cytochrome C, LDL, GNAO1, and estrogen receptor were the key molecules in this network. The gene discussed is ESR1; the disease is cancer.