In particular, astragaloside IV promotes hippocampal neurogenesis in the intact brain, and astragaloside VI induces proliferation of neural stem cells (NSCs) in the subventricular zone (SVZ) and peri-infarct cortex via activating the epidermal growth factor receptor (EGFR)/mitogen-activated protein kinase (MAPK) pathway after a stroke (Huang et al., 2018; Chen et al., 2019). This evidence concerns the gene WNK2 and stroke disorder.