Thus, the present study further examined whether the combination treatment could induce endogenous oligodendrogenesis and overcome the intrinsic axonal growth-inhibitory pathways NogoA/NgR and RhoA/ROCK2, thus, providing us with valuable insight into the beneficial effects of a combined therapeutic approach of XSEC and EE interventions on axonal remodeling after an ischemic stroke. This evidence concerns the gene RTN4R and ischemic stroke.