The expression of α-klotho was modulated by several physiological and pathological factors, including acute inflammatory stress, oxidative stress, diabetes mellitus, hypertension, and chronic renal failure (Ohyama et al., 1998; Utsugi et al., 2000; Moreno et al., 2011; Asai et al., 2012; Qiu et al., 2016; Poelzl et al., 2018). Here, KL is linked to hypertensive disorder.