Variants in RyR2 are classically linked to the inherited arrhythmogenic disease Catecholaminergic polymorphic ventricular tachycardia (CPVT), although RyR2 missense mutations have also been found in ACM patients (Tiso et al., 2001). The gene discussed is RYR2; the disease is catecholaminergic polymorphic ventricular tachycardia.