For example, Warsinske et al. simulated granuloma-associated fibrosis by incorporating a system of ODEs and PDEs that describe molecular level diffusion of chemokines (TGFβ and prostaglandin) and receptor ligand signaling, coupled with discrete cellular agents whose behaviors were defined by a set of rules that related receptor activation levels to cell proliferation, differentiation, chemotaxis, and secretion of ECM proteins. This evidence concerns the gene TGFB1 and Granuloma.