Recently, transcription factor EB (TFEB) was identified to regulated the transcription of various genes involved in autophagy and lysosomal biogenesis, and inhibition of the mammalian target of rapamycin (mTOR) has been shown to protect podocyte injury by promoting nuclear translocation of TFEB in animal models of DN (Settembre et al.,2011; Settembre et al., 2013). The gene discussed is TFEB; the disease is liver dysplastic nodule.