RPS6KB1 and non-small cell lung carcinoma: The degree of inhibition of the PI3K/Akt/mTOR pathway was mediated by the application of sotetsuflavone in NSCLC A549 cells which we confirmed by way of reducing the level and degree of phosphorylation of PI3K, Akt, mTOR, Raptor, and p70S6K (Figure 4).